Double muscling in cattle and malignant hyperthermia in pigs: common features
نویسندگان
چکیده
منابع مشابه
Myostatin Mutations Cause Double Muscling in Cattle
The differences between humans and farm animals are obvious, from body structure to diet to reproduction. Unlike humans, swine have litters of young; cattle are ruminants; and sheep are woolly. Despite such significant differences, growth and development of mammalian species is very similar. The biological controls that govern the establishment of body axes, induction and morphogenesis of tissu...
متن کاملDouble Muscling in Cattle: Genes, Husbandry, Carcasses and Meat
Molecular biology has enabled the identification of the mechanisms whereby inactive myostatin increases skeletal muscle growth in double-muscled (DM) animals. Myostatin is a secreted growth differentiation factor belonging to the transforming growth factor-β superfamily. Mutations make the myostatin gene inactive, resulting in muscle hypertrophy. The relationship between the different character...
متن کاملMalignant Hyperthermia: Evaluation of “Organon” 9426 in Malignant Hyperthermia Susceptible Pigs
Control pigs required 109.9 ug/kg/min and MHS pigs required 72.4 ug/kg/min infusion of Organon 9426 to maintain a 90% block. It appears that Organon 9426 is only one-third to one-half as potent as Vecuronium in pigs. The fact that MHS pigs only require 66% of the infusion dose to maintain a 90% block suggests that there is difference in the neuromuscular effect of Organon 9426 in MHS vs. contro...
متن کاملMalignant Hyperthermia
''Malignant Hypothermia'' syndrome is a rare, but dangerous occurrence, the aetiology of which is not known. Up to this date 180 cases have been reported. This syndrome i's seen generally in :male children over age of two years, and especially in adolescent males. Also those people with muscular abnormalities are more susciptable to this illnes'S. Anaesthetic agent such as halothane or muscular...
متن کاملDouble muscling in cattle due to mutations in the myostatin gene.
Myostatin (GDF-8) is a member of the transforming growth factor beta superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass in mice. Here we report the myostatin sequences of nine other vertebrate species and the identification of mutations in the coding sequence of bovine myostatin in two breeds of double-muscled cattle, Belgi...
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ژورنال
عنوان ژورنال: Genetics Selection Evolution
سال: 1977
ISSN: 1297-9686
DOI: 10.1186/1297-9686-9-1-140a